What are the current GOLD guidelines criteria for prescribing LTOT in stable COPD? Specifically, what PaO2 and SpO2 thresholds trigger initiation, how many hours/day should it be used, and does it improve survival in all COPD patients or only specific subgroups (e.g., those with resting hypoxemia vs exercise-induced desaturation)?
Be specific. Cite references where possible. Your credentials will be shown with your answer.