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Comparing smoking cessation pharmacotherapy: NRT vs varenicline vs bupropion β€” which to choose and when?

Prabhu Kvn
Prabhu Kvn
Other
πŸ‘ 23 viewsπŸ’¬ 0 answersπŸ• Apr 14, 2026
⚠For peer discussion only β€” not a substitute for clinical judgment. Always verify with authoritative sources.

A 50-year-old male smoker (25 cigarettes/day for 30 years) wants to quit. He has mild depression and is currently on sertraline. He has tried NRT patches twice without success. How do we choose between varenicline, bupropion, and NRT combination in this patient? Are there any safety concerns with varenicline in patients on antidepressants or with psychiatric history?

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πŸ‘ Views23
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πŸ• Asked Apr 14, 2026
Asked by
Prabhu Kvn
Prabhu Kvn
Other
⭐ 48 reputation
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