Best approach to managing acute exacerbation of COPD in the emergency setting?

A 68-year-old male with known COPD (GOLD stage III) presents with worsening dyspnea, increased sputum production, and SpO2 of 82% on room air. He is tachypneic with RR 28/min and using accessory muscles. What are the key priorities in initial management: optimal oxygen therapy targets, bronchodilator regimen, role of NIV, and criteria for ICU transfer?