Optimal lung-protective ventilation strategy in moderate-to-severe ARDS — tidal volume, PEEP, and prone positioning

A 40-year-old patient with sepsis-induced ARDS has PaO2/FiO2 ratio of 95 on 60% FiO2. They are on volume-controlled ventilation. What are the current evidence-based recommendations for tidal volume (ARDSnet), optimal PEEP strategy (high vs low PEEP), prone positioning criteria and duration, and role of neuromuscular blockade in early severe ARDS?